Effective treatment of Kimura’s disease with leflunomide in combination with glucocorticoids
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Lie Dai & Xiu-Ning Wei & Dong-Hui Zheng & Ying-Qian Mo & Frank Pessler & Bai-Yu Zhang
- چاپ و سال / کشور: 2011
Description
Kimura’s disease (KD) is a rare, benign, chronic inflammatory disease which typically presents as persisting or recurring tumor-like lesions in the head and neck area that can be easily misdiagnosed.We report one patient with KD treated with leflunomide in combination with glucocorticoids and analyzed the literature on treatment of KD. The patient had a recurrent mass in the left upper arm with eosinophilia and elevated serum IgE but no renal involvement. The clinical manifestations improved markedly within 1 month, and blood eosinophil count and serum IgE normalized. Corticosteroids were then tapered gradually without recurrence or severe side effects in the 2-year follow-up period. Literature analysis identified four different non-drug interventions and 18 different drugs for treating KD, most of which were obtained from case reports. Our use of combination therapy of leflunomide and glucocorticoids suggests the need for a controlled trial for the treatment of this rare disorder.
Clin Rheumatol (2011) 30:859–865 Received: 23 December 2010 / Accepted: 7 January 2011 / Published online: 1 February 2011
