Single-nucleotide polymorphisms of MAMDC1 are associated with rash and photosensitivity, but not disease risk, of systemic lupus erythematosus in Chinese mainland population
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Qi Wu & Bo Yu & Yuewen Chen & Yong Shao & Jie Zhang & Qili Zhong & Xi Peng & Hong Yang & Xiaoping Hu & Bancheng Chen & Ming Guan & Jun Wan &Wei Zhang
- چاپ و سال / کشور: 2011
Description
Systemic lupus erythematosus (SLE) is a complex immune disease affected by both genetic dispositions and environmental factors. Recently, the polymorphisms in MAMDC1 gene have been reported to associate with disease risk of SLE in European population. However, whether this association is replicated in Chinese population is unknown yet. A total of 491 SLE patients and 533 controls were recruited. Unlabeled probe-based high-resolution melting analysis (HRMA) was used in genotyping. HRMA with unlabeled probe successfully distinguished all genotypes. SNP rs961616 was associated with rash [P=0.015, odds ratio (OR)=0.73, 95% confidence interval (CI)=0.57–0.94] and photosensitivity (P=0.001, OR=0.63, 95%CI=0.48–0.84), but not the disease risk (P=0.133, OR=0.88, 95%CI=0.74– 1.04), of SLE in Chinese population. Polymorphisms of rs961616 in MAMDC1 gene were associated with rash and photosensitivity, but not disease risk, of systemic lupus erythematosus in Chinese population.
Clin Rheumatol Received: 1 November 2010 / Revised: 22 May 2011 / Accepted: 2 June 2011
