Clinical relevance of angiopoietin-1, angiopoietin-2, and their receptor Tie-2 expression in acute myeloid leukemia
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Safaa M. El Karaksy & Nancy M. El Guindy & Heba M. Gouda & Mervat M. Khorshied & Iman A. Shaheen & Reham E. Abu Khalil & Noha Y. Ibrahim
- چاپ و سال / کشور: 2010
Description
The angiogenic-related factors, angiopoietin-1 and angiopoietin-2 and their receptor Tie-2, have wide-ranging effects on tumor behavior that includes angiogenesis and inflammation. These multifaceted pathways present a potential target in developing novel inhibition strategies for cancer therapy. The present work aimed at detecting the prevalence of expression of angiopoietin-1, angiopoietin-2, and their receptor Tie-2 in 56 Egyptian de novo acute myeloid leukemia (AML) patients by conventional RT-PCR to verify the prognostic impact of their expression on the response to induction chemotherapy. Thirty age- and sex-matched healthy volunteers were subjected to the same analysis as a control group. High expression of Ang-1 was detected in the patient group but not the control group. AML patients expressing Ang-2 either solely or in combination with high Ang-1 and/or Tie-2 showed unfavorable response to induction chemotherapy, either failed induction or death during induction. These data provide evidence that the alternation of angiopoietin balance in favor of Ang-2 may play a critical role in the pathophysiology of AML. Furthermore, positive pretherapeutic expression of Ang-2 indicates viable unfavorable prognostic marker in AML patients and may be used as a prognostic tool in the risk-adaptive management of AML.
Comp Clin Pathol (2011) 20:341–347 DOI 10.1007/s00580-010-1000-y Received: 10 January 2010 / Accepted: 25 March 2010 / Published online: 14 April 2010
