Subacute toxicity study of the methanolic seed extract of Buchholzia coriacea (Capparaceae) in rats
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Nwakaego Ernestina Nweze & Boniface M. Anene & Isaac U. Asuzu & Wilfred S. Ezema
- چاپ و سال / کشور: 2011
Description
The methanol extract of Buchholzia coriacea seed has shown some anti-trypanosomal activity against Trypanosoma brucei brucei. The acute toxicity test of this extract showed no signs of toxicity. This present study was designed to assess its sub-acute toxicity in rats. Rats of both sexes were dosed daily with 125, 250 and 500 mg/kg body weight of the extract by oral gavage for 28 days. Dosing with the extract showed no significant effect on body weights. The temperatures of extract-treated rats were significantly (p<0.05) higher during the first and last weeks of the experiment. There were also significant reductions (p<0.05) of red and white blood cell counts, packed cell volumes and haemoglobin concentrations in the extracttreated animals. Blood biochemistry revealed no significant changes. On necropsy, pale mucous membranes, bile stains on spleen, congestion of the lungs and caudal lobes of the liver were evident in the extract-treated rats. There were significant (p<0.05) reductions in relative liver weights of the extract-treated male rats. Twenty-eight days dosing of rats with the methanol extract of B. coriacea seed caused signs of toxicity at the tested doses.
Comp Clin Pathol DOI 10.1007/s00580-011-1210-y Received: 14 December 2010 / Accepted: 8 February 2011
