Effect of topical 0.5% timolol maleate on tear production as measured by Schirmer tear test in clinically normal horses
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Masoud Selk Ghaffari & Amin Sabzevari & Ramin Hajikhani & Alexandra Trbolova
- چاپ و سال / کشور: 2011
Description
The current study was undertaken to evaluate the effects of topical 0.5% timolol maleate on tear production in clinically normal horses. Fourteen horses free from clinically relevant ocular abnormalities were used in the study. The 14 horses were randomly assigned to a treatment or control group. The treatment group included seven horses that received 0.25 mL of 0.5% timolol maleate ophthalmic solution in a randomly chosen eye, and the opposite eye served as the untreated control. The control group included seven horses that received no topical medications during the study. Schirmer tear test was performed on both eyes of all horses 1 day prior to treatment (T0) and then at 1, 3, 7, and 14 days of treatment (T1, T3, T7, and T14). In the treatment group, the baseline (T0) Schirmer tear test (STT) values in the treated and non-treated eyes were 25.5}3.8 and 26.1} 6.6, respectively. In the control group, baseline mean}SD STTs were 21.4}3.6 and 24.2}4.4 in the right and left eyes, respectively. Baseline STTs between the treatment and control groups were not significantly different (P.0.97). There was no statistically significant change in STT values throughout the study period in treatment and control groups (P.0.15). In Conclusion, twice daily topical application of 0.5% timolol maleate had no significant effect on tear secretion when administered over a 2-week period in clinically normal horses.
Comp Clin Pathol DOI 10.1007/s00580-011-1203-x Received: 12 November 2010 / Accepted: 8 February 2011
