The signification of antiphospholipid antibodies in pregnancy-associated pathologies and venous thromboembolism
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Sarra Klai & Najiba Fekih-Mrissa & Ridha Mrissa & Radhouen Rachdi & Nasredine Gritli
- چاپ و سال / کشور: 2010
Description
Women with antiphospholipid antibodies are at high risk of pregnancy complications. Three hundred and two women with pregnancy complications matched with 100 women having a past history of uncomplicated pregnancy outcome were screened for the presence of antiphospholipid antibodies such as lupus anticoagulant and immunoglobulin G (IgG)/M antibodies for cardiolipin. Among the overall positivity for any one of the antiphospholipid antibodies studied, significant associations were found with recurrent pregnancy loss (OR 16.87; 95% CI, 5.5–51.63, p<10-3), intrauterine growth retardation (OR 3.9; 95% CI, 1.08–14.05, p=0.04) and preeclampsia (OR 4.54; 95% CI, 1.25–16.42, p=0.035). IgG was considered a risk factor for recurrent pregnancy loss (OR 15.31; 95% CI, 3.37–69.7, p<10-3) and intrauterine growth retardation (OR 6.7; 95% CI, 1.3–34.4, p=0.017). The lupus anticoagulant was associated only with recurrent pregnancy loss (OR 12.4; 95% CI, 1.48–103.1, p=0.006).
Comp Clin Pathol DOI 10.1007/s00580-010-1119-x Received: 26 July 2010 / Accepted: 8 October 2010
