Anti-diabetic effect of orally administered Otostegia persica extract on streptozotocin diabetic rats
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Mohammad Reza Ebrahimpoor & Zabihollah Khaksar & Ali Noorafshan
- چاپ و سال / کشور: 2010
Description
Anti-diabetic effect of the alcoholic extract of Otostegia persica was investigated on 40 streptozotocin diabetic rats in four equal groups. Animals in the first group did not receive any extract and acted as a control for the other groups. Rats in group II, III, and IV received a daily oral dose of O. persica extract at 200, 350, and 500 mg/kg, respectively, for 3 weeks. Blood glucose level was estimated three times a day (8:00 and 11:00 AM and 5:30 PM) in all groups. Statistical analysis of the results by t test showed that the extract produced a dose-dependent decrease in the blood glucose level especially in the fourth group (p<0.0001) in comparison the control group. Thus, study indicates that O. persica has a strong anti-diabetic action and can decrease blood glucose levels.
Comp Clin Pathol DOI 10.1007/s00580-010-1030-5 Received: 12 January 2010 / Accepted: 26 May 2010
