Cerebrum malformation in offspring of diabetic mothers
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Zabihollah Khaksar & Gholamali Jelodar & Hooman Hematian
- چاپ و سال / کشور: 2010
Description
This study was conducted to evaluate effects of maternal diabetes on fetal brain structure especially in cerebrum. Sixteen adult female rats were divided in two groups. Diabetes was induced in one group by alloxan agent. Both groups became pregnant by natural matting. At 7, 14, 21, and 28 days after birth, the cerebrum was collected from offspring of all rats and the weight of neonates was measured. Various histological parameters were determined using histological techniques. Results revealed a significant decrease in number of cells in gray matter and white matter in all days after birth and a significant decrease in thickness of gray matter at 7 and 14 days postneonatal in cerebrum of offspring of diabetic mothers (ODM) as compared with control group. The body weight of ODM was significantly more than that of control (p< 0.05). Maternal hyperglycemia exhibited deleterious effects on brain specially cerebrum during fetal life, which remained persistent during postneonatal period.
Comp Clin Pathol DOI 10.1007/s00580-010-1160-9 Received: 24 August 2010 / Accepted: 7 December 2010
