Experimental studies on anaemia in riverine buffaloes (Bubalus bubalis) infected with Fasciola gigantica
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : R. Edith & R. L. Sharma & Rajesh Godara & M. B. Thilagar
- چاپ و سال / کشور: 2010
Description
The pathogenesis of Fasciola gigantica-induced anaemia was experimentally investigated in riverine buffalo yearlings of Murrah breed. Eight male buffaloes, aged 12– 15 months were randomly assigned to two groups (infected animals (Gr-I) and healthy controls (Gr-II)) of four animals each. Animals in Gr-I were orally administered 800 F. gigantica metacercariae (bubaline origin). Animals in Gr-II, served as uninfected healthy controls. Weekly fluctuations in the haematological parameters and egg per gram of feaces were monitored until day 112 post-infection. The infection caused a significant increase in erythrocyte sedimentation rate, total leucocyte counts and eosinophils and a significant fall (p<0.01) in haemoglobin concentration, packed cell volume and total erythrocyte counts. The percentage fall in the erythrocytic indices was the highest during late prepatency and at times touched critical levels. Further analysis of the data revealed that the Gr-I suffered from the normocytic normochromic anaemia during prepatency (up to week 6 PI). Subsequently, the picture shifted to macrocytic hypochromic anaemia. The Gr-II were in perfect health and within normal range fluctuations of above parameters throughout the period of investigation. Possible sequence of events vis-à-vis deleterious effects of the fluke on circulating erythrocytes have been discussed during the course of the disease.
Comp Clin Pathol DOI 10.1007/s00580-010-1109-z Received: 22 March 2010 / Accepted: 29 September 2010
