Omalizumab: Anti-IgE Therapy in Allergy
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Matthias Volkmar Kopp
- چاپ و سال / کشور: 2011
Description
Omalizumab is a humanized, monoclonal anti- IgE antibody that binds specifically to circulating IgE molecules, thus interrupting the allergic cascade. Omalizumab has been shown to be highly effective in treating children and adults with moderate to severe allergic asthma. Beyond this indication, the mode of action itself suggests that omalizumab is not only an antiasthmatic drug but also a promising therapeutic option for various allergic conditions, including allergic rhinitis, food allergy, urticaria, allergic bronchopulmonary aspergillosis, insect hypersensitivity, and atopic dermatitis. However, data from doubleblind, placebo-controlled clinical trials are only available for allergic rhinitis and moderate to severe bronchial asthma. The aim of this review is to discuss the current clinical data as well as possible further indications of omalizumab treatment
Curr Allergy Asthma Rep (2011) 11:101–106 DOI 10.1007/s11882-010-0173-4 Published online: 18 January 2011
