Interleukin-33 in Asthma: How Big of a Role Does It Play?
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Larry Borish & John W. Steinke
- چاپ و سال / کشور: 2010
Description
In complex disorders such as asthma and allergic disease, the goal for developing disease-modifying biotherapeutics is to find a target that is a central instigator of immunologic activity. Interleukin (IL)-33 seems to be such a molecule, as it is one of the earliest-released signaling molecules following epithelial damage and can orchestrate the recruitment and activation of the cells responsible for disease. Unregulated IL-33 activity leads to activation of T-helper type 2 cells, mast cells, dendritic cells, eosinophils, and basophils, ultimately leading to increased expression of cytokines and chemokines that define the disease. As such, IL-33 is an attractive candidate for therapeutic intervention with the goal of ameliorating disease. This review focuses on the role of IL- 33 in promoting and maintaining the asthma phenotype
Curr Allergy Asthma Rep (2011) 11:7–11 DOI 10.1007/s11882-010-0153-8 Published online: 8 October 2010
