The Role of Lipoprotein-Associated Phospholipase A2 as a Marker and Potential Therapeutic Target in Atherosclerosis
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Ralph A. H. Stewart & Harvey D. White
- چاپ و سال / کشور: 2011
Description
Lipoprotein-associated phospholipase A2 (Lp- PLA2) is an enzyme that generates inflammatory mediators within atherosclerotic plaques. In epidemiologic studies there is an association between higher plasma Lp-PLA2 activity and myocardial infarction, stroke and cardiovascular mortality. In animal models, darapladib, a specific inhibitor of Lp-PLA2, decreases the size of the atheroma necrotic core and plaques with thin fibrous caps. Early clinical trials suggest darapladib effectively and safely inhibits Lp-PLA2 activity both in plasma and in carotid atheroma. Two large phase III clinical trials that are currently in progress will determine whether darapladib will reduce the risk of myocardial infarction, stroke, and cardiovascular death by stabilizing atherosclerotic plaques
Curr Atheroscler Rep (2011) 13:132–137 DOI 10.1007/s11883-010-0158-8 Published online: 5 January 2011
