Lecithin Cholesterol Acyltransferase:An Anti- or Pro-atherogenic Factor?
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Xavier Rousset & Robert Shamburek & Boris Vaisman & Marcelo Amar & Alan T. Remaley
- چاپ و سال / کشور: 2011
Description
Lecithin cholesterol acyl transferase (LCAT) is a plasma enzyme that esterifies cholesterol and raises highdensity lipoprotein cholesterol, but its role in atherosclerosis is not clearly established. Studies of various animal models have yielded conflicting results, but studies done in rabbits and non-human primates, which more closely simulate human lipoprotein metabolism, indicate that LCAT is likely atheroprotective. Although suggestive, there are also no biomarker studies that mechanistically link LCAT with cardiovascular disease. Imaging studies of patients with LCAT deficiency have also not yielded a clear answer to the role of LCAT in atherosclerosis. Recombinant LCAT, however, is currently being developed as a therapeutic product for enzyme replacement therapy of patients with genetic disorders of LCAT for the prevention and/or treatment of renal disease, but it may also have value for the treatment of acute coronary syndrome.
Curr Atheroscler Rep (2011) 13:249–256 DOI 10.1007/s11883-011-0171-6 Published online: 18 February 2011
