Hedgehog Pathway Inhibitors: Potential Applications in Breast Cancer
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Yee Hong Chia & Cynthia X. Ma
- چاپ و سال / کشور: 2010
Description
The Hedgehog (Hh) signaling pathway is a developmental pathway with important roles in embryogenesis, epithelial-mesenchymal transition, stem/progenitor cell renewal, and tissue regeneration and repair. Dysregulated Hh signaling is implicated in 25% of human cancers, including breast cancer. Mutations within elements of the Hh signaling pathway leading to ligand-independent activation do not appear to be widespread in breast cancer. However, overexpression of the Hh ligand and Hh target genes has been reported in breast cancer, suggesting a ligand-dependent mechanism for Hh pathway activation in breast carcinogenesis. Small molecule antagonists of the Hh pathway are under clinical development and may present novel therapeutic options for breast cancer.
Curr Breast Cancer Rep (2011) 3:15–23 DOI 10.1007/s12609-010-0031-3 Published online: 3 December 2010
