The Heterogeneous Biomechanics and Mechanobiology of the Mitral Valve: Implications for Tissue Engineering
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : K. Jane Grande-Allen & Jun Liao
- چاپ و سال / کشور: 2011
Description
There are compelling reasons to develop a tissueengineered mitral valve, but this endeavor has not received the same attention as tissue engineering strategies for the semilunar valves. Challenges in regenerating a mitral valve include recapitulating the complex heterogeneity in terms of anatomy (differently sized leaflets, numerous chordae), extracellular matrix composition, biomechanical behavior, valvular interstitial cell and endothelial cell phenotypes, and interior vasculature and innervation. It will also be essential to restore the functional relationships between the native mitral valve and left ventricle. A growing amount of information relevant to tissue engineering amitral valve has been recently collected through investigations of cell mechanobiology and collagen organization. It is hoped that the development of tissue-engineered mitral valves can build on knowledge derived from engineering semilunar valves, but the mitral valve will present its own unique challenges as investigators move toward a first-generation prototype
Curr Cardiol Rep (2011) 13:113–120 DOI 10.1007/s11886-010-0161-2 Published online: 8 January 2011
