Cardiovascular Risk in the Old Order Amish
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Maya Y. Peltsverger & Francesco Saverio Celi
- چاپ و سال / کشور: 2011
Description
Cardiovascular disease is a heterogeneous disease caused by the interaction of multiple pathologies affecting various systems, genetic predisposition, and environmental factors. Recently, novel “non-classic” risk factors have been recognized to play, together with wellcharacterized risk factors, a role in the pathophysiology of cardiovascular disease. The heterogeneity of causative factors makes identifying the genetic background along with the contribution of environmental influences on the development and progression of cardiovascular disease a major challenge. The Old Order Amish of Lancaster County, Pennsylvania, a close founder population with a very traditional and uniform lifestyle and well-traceable genealogy, is a unique and valuable source of information with respect to the genetic contribution of risk factors that potentially lead to the development of cardiovascular disease. In this review, the major findings from studies of the Old Order Amish are described along with the relevance of these findings to larger population groups.
Curr Cardiovasc Risk Rep (2011) 5:207–214 DOI 10.1007/s12170-011-0163-7
