Clinical Utility of Multiple Biomarker Panels for Cardiovascular Disease Risk Prediction
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Maria Hughes & Frank Kee & Veikko Salomaa
- چاپ و سال / کشور: 2011
Description
Current cardiovascular risk prediction is imprecise, with clinical treatment aimed at those with high risk of disease while neglecting those at intermediate risk who might benefit from early treatment. Biomarkers can capture features of subclinical atherosclerosis, but although many studies have shown their association with cardiovascular risk, whether they can improve the performance of prediction algorithms is contested. The combined use of multiple biomarkers offers promise for refining risk assessment by adding incremental information from different pathophysiologic pathways. The utility of certain combinations of multiple biomarkers has been shown to have greatest effect in selected patient subgroups (ie, middle-aged men and those at intermediate risk). Carefully designed randomized controlled trials are needed to understand the clinical implications of risk stratification using multiple biomarker panels.
Curr Cardiovasc Risk Rep (2011) 5:165–173 DOI 10.1007/s12170-010-0153-1 Published online: 11 January 2011
