Reduced Chemotherapy Duration: A Good Idea?
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Joleen Hubbard & Axel Grothey
- چاپ و سال / کشور: 2011
Description
Over the past three decades, survival outcomes of high-risk stage II and stage III colon cancer have improved with the use of adjuvant chemotherapy. Oxaliplatin and fluoropyrimidine combination regimens, given for 6 months, are the current standard of care. However, chronic peripheral neuropathy can result as a side effect of oxaliplatin use. Investigators have questioned whether the recommended duration of adjuvant therapy is necessary. This review discusses the history of adjuvant therapy for colon cancer and provides a rationale for an ongoing clinical trial collaboration addressing the optimal duration of adjuvant therapy.
Curr Colorectal Cancer Rep (2011) 7:241–245 DOI 10.1007/s11888-011-0100-7 Published online: 10 June 2011
