One Size Does Not Fit All: Planning Volumes for Radiotherapy in Rectal Cancer—Should We Tailor Radiotherapy Fields to Stage and Risk?
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Louise Dulley & Mark Harrison & Rob Glynne-Jones
- چاپ و سال / کشور: 2010
Description
The optimal clinical target volume (CTV) in preoperative radiotherapy and chemoradiotherapy for resectable rectal cancer prior to total mesorectal excision (TME) remains poorly defined. TME does not remove all nodal stations potentially harboring subclinical disease. A literature search was employed to identify studies exploring planning volumes in preoperative radiotherapy and chemoradiation schedules. There are few studies of local recurrence after TME mainly relating to short course preoperative radiotherapy (SCPRT), and even fewer to chemoradiotherapy. Lymph nodes and their precise location are well described in Japanese and Korean, but not generally in Western series. We recommend customized CTV delineations based on site and stage according to clinical and MRI staging, with adaptations for high-risk features. Although these proposed CTV delineations have not been evaluated in randomized trials, their use appears rational and based on current evidence
Curr Colorectal Cancer Rep (2011) 7:89–96 DOI 10.1007/s11888-010-0075-9 Published online: 24 December 2010
