Gut Microbiota and the Pathogenesis of Insulin Resistance
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Nathalie M. Delzenne & Patrice D. Cani
- چاپ و سال / کشور: 2011
Description
Several reviews recently explored how the gut microbiota was able to control host energy metabolism, and thereby the development of adiposity. In this review, we focused on the state of the art that supports a link between the gut microbiota composition and activity, and the management of glycemia associated with overweight and diabetes. Several microbial-derived compounds are related to disturbances of glucose homeostasis including the gramnegative– derived lipopolysaccharides. Some nutrients with prebiotic properties, which escape the digestion in the upper part of the gut, modify the composition of the gut microbiota in favor of bacteria that could play a beneficial role on glucose homeostasis, namely by modulating the endocrine function of the gut, and by reinforcing the gut barrier. Adequate intervention studies in diabetic patients are required to assess the relevance of those experimental data for human health.
Curr Diab Rep (2011) 11:154–159 DOI 10.1007/s11892-011-0191-1 Published online: 24 March 2011
