Fluconazole-Resistant Candida: Mechanisms and Risk Factor Identification
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : MarkAlain Déry & Rodrigo Hasbun
- چاپ و سال / کشور: 2011
Description
The extensive use of fluconazole in the previous two decades has fostered the emergence of azole-resistant strains, including non-albicans species such as C. glabrata. The main mechanisms of fluconazole resistance described involve alteration of the quality or quantity of 14-alpha-demethylase enzyme or reduced access of the drug to the target enzyme by upregulation of efflux pumps. Fluconazole prophylaxis has been used successfully to prevent fungal infections in highrisk neonates, neutropenic patients, individuals with HIV infection, recipients of solid organ (eg, liver) transplants and bone marrow transplants, and patients in intensive care units, with a small increase in the risk of colonization, but not infection, with fluconazole-resistant Candida isolates. Among other risk factors, recent fluconazole exposure is associated with fluconazole-resistant candidemia.
Curr Fungal Infect Rep (2011) 5:23– DOI 10.1007/s12281-010-0045-3 Published online: 11 January 201128
