Antifungal Dosing in Obesity: A Review of the Literature
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Jarrett R. Amsden & Douglas Slain
- چاپ و سال / کشور: 2011
Description
Obesity is becoming a global pandemic that is projected to increase significantly over the next few decades. Unfortunately, studies of drug dosing and pharmacokinetics have largely excluded obese patients. Currently, literature inadequately characterizes drug disposition in these patients. Only a limited selection of literature addresses antibacterial dosing in obesity, and virtually none characterizes antifungal dosing in obesity. This review discusses the changes in pharmacokinetics that occur in obesity and the available in vitro and in vivo data describing the disposition of antifungal agents in obese animals and patients.
Curr Fungal Infect Rep (2011) 5:83–91 DOI 10.1007/s12281-011-0049-7 Published online: 26 March 2011
