Candidemia in the Pediatric Intensive Care Unit: What’s Different from Candidemia in Adults?
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : John Dotis & Emmanuel Roilides
- چاپ و سال / کشور: 2010
Description
Candida species bloodstream infections have been associated with high morbidity and mortality, especially in patients hospitalized in a pediatric intensive care unit (PICU). The incidence of such infections is rising because of malignancies, prolonged PICU stay, and the use of broad-spectrum antibiotics. Although Candida albicans remains the most frequently isolated species, non-albicans Candida species have shown an increased frequency. Treatment with fluconazole or an echinocandin should be considered in patients at high risk for candidemia or as initial treatment for non-neutropenic patients with candidemia, in addition to the removal of intravascular catheters. Treatment with a lipid formulation of amphotericin B or caspofungin is suggested for neutropenic patients. Early diagnosis, prompt therapy, and prevention are the cornerstones of controlling infection and improving outcome. Although there are some differences between children and adults with candidemia, especially in antifungal drug therapy and outcome, in general the incidence, risk factors, species variation, diagnostic methods, and management are similar.
Curr Fungal Infect Rep (2011) 5:49–55 DOI 10.1007/s12281-010-0043-5 Published online: 29 December 2010
