A Clinical Perspective on Gastric Neuroendocrine Neoplasia
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Ben Lawrence & Mark Kidd & Bernhard Svejda & Irvin Modlin
- چاپ و سال / کشور: 2010
Description
The incidence of gastric neuroendocrine tumors (NETs) has increased exponentially based on widespread use of endoscopy and a greater pathological awareness of the condition. A key concern is the potential association with hypergastrinemia induced by proton pump inhibitor administration. Previous confusion regarding diagnosis and therapy has been diminished by a series of international consensus statements defining the biology and management strategies for the disease. Overall, gastric NETs are categorized as welldifferentiated or poorly differentiated neoplasms. Welldifferentiated gastric NETs are enterochromaffin-like (ECL) cell tumors subclassified into three types based on their relationship to gastrin, a key regulator of ECL cell neoplastic transformation. The treatment of type 1 and type 2 tumors depends on the size and invasiveness of the tumor, whereas type 3 tumors and poorly differentiated neuroendocrine carcinomas warrant aggressive surgical resection. The disease-specific 5-year survival ranges from about 95% in type 1 gastric carcinoids to about 25% in poorly differentiated gastric NECs. Elucidation of the precise biology of a gastric NET is critical to diagnosis and delineation of a typespecific management strategy.
Curr Gastroenterol Rep (2011) 13:101–109 DOI 10.1007/s11894-010-0158-4 Published online: 16 November 2010
