Beta-3 Adrenoceptors as New Therapeutic Targets for Cardiovascular Pathologies
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Chantal Gauthier & Bertrand Rozec & Boris Manoury & Jean-Luc Balligand
- چاپ و سال / کشور: 2011
Description
Catecholamines play a key role in the regulation of cardiovascular function, classically through ک1/2- adrenoreceptors (AR) activation. After ک3-AR cloning in the late 1980s, convincing evidence for ک3-AR expression and function in cardiovascular tissues recently initiated a reexamination of their involvement in the pathophysiology of cardiovascular diseases. Their upregulation in diseased cardiovascular tissues and resistance to desensitization suggest they may be attractive therapeutic targets. They may substitute for inoperant ک1/2-AR to mediate vasodilation in diabetic or atherosclerotic vessels. In cardiac ventricle, their contractile effects are functionally antipathetic to those of ک1/2-AR; in normal heart, ک3-ARs may mediate a moderate negative inotropic effect, but in heart failure, it may protect against adverse effects of excessive catecholamine stimulation by action on excitation-contraction coupling, electrophysiology, or remodelling. Thus, prospective studies in animals and patients at different stages of heart failure should lead to identify the best therapeutic window to use ک3-AR agonists and/or antagonists
Curr Heart Fail Rep (2011) 8:184–192 DOI 10.1007/s11897-011-0064-6 Published online: 2 June 2011
