Soluble Guanylate Cyclase Modulators in Heart Failure
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Veselin Mitrovic & Ana Jovanovic & Stefan Lehinant
- چاپ و سال / کشور: 2011
Description
This review summarizes the role of soluble guanylate cyclase (sGC)-cyclic guanosine 3پŒ, 5پŒ-monophosphate pathways in heart failure and several new drugs that modify guanylate cyclase. The sGC activators and stimulators as modulators of sGC are promising drugs in the therapy for decompensated heart failure and pulmonary hypertension. Cinaciguat is a nitric oxide (NO).independent direct activator of sGC, which also may be effective under oxidative stress conditions resulting in oxidized or heme-free sGC refractory to organic nitrates. Riociguat is an NO-independent direct stimulator of sGC with beneficial effects in patients with decompensated heart failure and pulmonary hypertension. The sGC modulators play an important role in patients with heart failure and pulmonary hypertension
Curr Heart Fail Rep (2011) 8:38–44 DOI 10.1007/s11897-010-0045-1 Published online: 5 January 2011
