The Role of Transplantation in Diffuse Large B-Cell Lymphoma: The Impact of Rituximab Plus Chemotherapy in First-line and Relapsed Settings
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Celso Arrais Rodrigues & Poliana Alves Patah & Yana A. S. Novis & Chitra Hosing & Marcos de Lima
- چاپ و سال / کشور: 2010
Description
Rituximab has improved the prognosis of patients with diffuse large B-cell lymphoma, but a high proportion of patients with advanced disease will relapse or will fail to achieve a remission with front-line treatment. Salvage chemotherapy, followed by high-dose chemotherapy or radiation therapy and autologous stem cell transplantation, remains the best treatment option for such patients, especially those who retain chemosensitivity. Allogeneic transplantation is under investigation in this setting, often as a treatment for relapse after autologous transplantation. Treatment-related mortality due to graftversus- host disease, preparative regimen toxicity, and poor immune recovery often limits its benefits. This article reviews the role of hematopoietic stem cell transplantation in the treatment of diffuse large B-cell lymphoma, the incorporation of rituximab, and avenues of clinical investigation in this rapidly evolving field.
Curr Hematol Malig Rep (2011) 6:47–57 DOI 10.1007/s11899-010-0075-5 Published online: 30 December 2010
