Hepatitis B Genotypes: Role of Testing in Clinical Practice
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : W. Graham Cooksley
- چاپ و سال / کشور: 2011
Description
Hepatitis B viral genotypes influence natural history, with genotype Cmore likely to develop hepatocellular carcinoma than genotype B, thus influencing the need for intervention. In hepatitis B early antigen (HBeAg)-positive disease, the data with conventional interferon and pegylated interferon (peginterferon) provide compelling evidence that genotype A responds best. The argument for differentiating between genotypes B and C is less clear, but the response in genotype B appears better than in C. Loss of hepatitis B surface antigen (HBsAg) is alsomost common in genotype A. Patients with genotype A and B should be offered peginterferon as first-line therapy, because it offers potential for HBeAg seroconversion with a finite course of therapy. In HBeAg-negative disease, genotype A again gives the best response, although it is an uncommon genotype here. The response in other genotypes is also good, with 12%of patients losing HBsAg 5 years after treatment. Genotypes may also influence nucleoside resistance mutations and HBsAg loss.
Curr Hepatitis Rep (2011) 10:79–86 DOI 10.1007/s11901-011-0097-z Published online: 11 March 2011
