HCV Eradication: Implications for Disease Resolution
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Andrew Aronsohn & Donald Jensen
- چاپ و سال / کشور: 2010
Description
Hepatitis C virus (HCV) is a leading cause of liver-related death worldwide. The evolution of hepatitis C therapy has made serologic eradication of HCV RNA a reality for many patients. Although it is debated whether undetectable virus in the serum represents a cure with complete clearance of viral RNA from the host, improved clinical outcomes have been shown after successful treatment in patients who achieve a sustained virologic response (SVR). Specifically, patients with SVR have longer survival, reduced progression and, in some cases, regression of fibrosis, decreased likelihood of developing hepatocellular carcinoma, and improvement of many extrahepatic manifestations of HCV. This review discusses viral kinetics on therapy leading to eradication, identification, and clinical significance of occult HCV infection and clinical outcomes after successful treatment.
Curr Hepatitis Rep (2011) 10:27–32 DOI 10.1007/s11901-010-0076-9 Published online: 14 December 2010
