Improving the Diagnosis of Tuberculosis: From QuantiFERON to New Techniques to Diagnose Tuberculosis Infections
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Amy Y. Vittor & Joseph M. Garland & David Schlossberg
- چاپ و سال / کشور: 2011
Description
The diagnosis of latent and active tuberculosis in the HIV-positive population is challenged by diminished sensitivity of conventional tests, atypical presentations, and the lack of culture methods in the developing world, where the burden of co-infection is greatest. In response to these challenges, a variety of new diagnostics have emerged. These include interferon-gamma release assays for the diagnosis of latent tuberculosis (TB) infection and novel culture methods and molecular assays for the diagnosis of active tuberculosis. Although some tests (such as interferon-gamma release assays) are not clearly superior to existing diagnostics, other novel diagnostics, such as real-time polymerase chain reaction and the microscopic observed direct susceptibility assay hold much promise for prompt and accurate TB diagnosis in this population. Lineprobe, nitrate reductase, and mycobacteriophage assays have also provided rapid alternatives to conventional timeconsuming drug susceptibility testing and are critical to curtailing the spread of multidrug-resistant TB.
Curr HIV/AIDS Rep (2011) 8:153–163 DOI 10.1007/s11904-011-0083-7
