Pathogenesis of HIV in the Central Nervous System
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Victor Valcour & Pasiri Sithinamsuwan & Scott Letendre & Beau Ances
- چاپ و سال / کشور: 2010
Description
HIV can infect the brain and impair central nervous system (CNS) function. Combination antiretroviral therapy (cART) has not eradicated CNS complications. HIVassociated neurocognitive disorders (HAND) remain common despite cART, although attenuated in severity. This may result from a combination of factors including inadequate treatment of HIV reservoirs such as circulating monocytes and glia, decreased effectiveness of cART in CNS, concurrent illnesses, stimulant use, and factors associated with prescribed drugs, including antiretrovirals. This review highlights recent investigations of HIV-related CNS injury with emphasis on cARTera neuropathological mechanisms in the context of both US and international settings.
Curr HIV/AIDS Rep (2011) 8:54–61 DOI 10.1007/s11904-010-0070-4 Published online: 31 December 2010
