The Kidneys and Aldosterone/Mineralocorticoid Receptor System in Salt-Sensitive Hypertension
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Shigeru Shibata & Toshiro Fujita
- چاپ و سال / کشور: 2011
Description
Strong evidence supports the ability of the aldosterone/mineralocorticoid receptor (MR) system to dominate long-term blood pressure control. It is also increasingly recognized as an important mediator of cardiovascular and renal diseases, particularly in the presence of excessive salt intake. In a subgroup of individuals with metabolic syndrome, adipocyte-derived aldosterone-releasing factors cause inappropriate secretion of aldosterone in the adrenal glands during salt loading, resulting in the development of salt-induced hypertension and cardiac and renal damage. On the other hand, emerging data reveal that aldosterone is not a sole regulator of MR activity. We have identified the signaling crosstalk between MR and small GTPase Rac1 as a novel pathway to facilitate MR signaling. Such a local control system for MR can also be relevant to the pathogenesis of salt-sensitive hypertension, and future studies will clarify the detailed mechanism for the intricate regulation of the aldosterone/MR cascade.
Curr Hypertens Rep (2011) 13:109–115 DOI 10.1007/s11906-010-0175-6 Published online: 5 January 2011
