Potential Dopamine-1 Receptor Stimulation in Hypertension Management
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Mohammad Asghar & Seyed K. Tayebati & Mustafa F. Lokhandwala & Tahir Hussain
- چاپ و سال / کشور: 2011
Description
The role of dopamine receptors in blood pressure regulation is well established. Genetic ablation of both dopamine D1-like receptor subtypes (D1, D5) and D2-like receptor subtypes (D2, D3, D4) results in a hypertensive phenotype in mice. This review focuses on the dopamine D1-like receptor subtypes D1 and D5 (especially D1 receptors), as they play a major role in regulating sodium homeostasis and blood pressure. Studies mostly describing the role of renal dopamine D1-like receptors are included, as the kidneys play a pivotal role in the maintenance of sodium homeostasis and the long-term regulation of blood pressure. We also attempt to describe the interaction between D1-like receptors and other proteins, especially angiotensin II type 1 and type 2 receptors, which are involved in the maintenance of sodium homeostasis and blood pressure. Finally, we discuss a new concept of renal D1 receptor regulation in hypertension that involves oxidative stress mechanisms.
Curr Hypertens Rep (2011) 13:294–302 DOI 10.1007/s11906-011-0211-1 Published online: 3 June 2011
