Mild Cognitive Impairment in Parkinson’s Disease
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Dag Aarsland & Kolbjørn Brønnick & Tormod Fladby
- چاپ و سال / کشور: 2011
Description
Prospective studies conducted during the last decade have shown that the majority of patients with Parkinson’s disease (PD) develop dementia. In addition, using a variety of definitions and methods, more recent research suggests that approximately a quarter of PD patients without dementia have mild cognitive impairment (PD-MCI). Furthermore, several studies have shown that approximately 20% have MCI even at time of diagnosis of PD. The typical cognitive deficits include visuospatial, attentional, and executive deficits, but memory deficits have also been shown. The etiology of PD-MCI is not known, but it is likely that mechanisms known to contribute to dementia in PD (ie, limbic and cortical Lewy bodies, amyloid plaques, and cholinergic deficits) play a role, in addition to dysfunction of dopaminergic frontostriatal circuits. PD-MCI predicts a shorter time to dementia, and preliminary evidence suggests that this is particularly true for posterior cognitive deficits. There are currently no systematic clinical trials in PD-MCI.
Curr Neurol Neurosci Rep (2011) 11:371–378 DOI 10.1007/s11910-011-0203-1 Published online: 13 April 2011
