Differential Diagnosis of Chorea
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Ruth H. Walker
- چاپ و سال / کشور: 2011
Description
Chorea is a common movement disorder that can be caused by a large variety of structural, neurochemical (including pharmacologic), or metabolic disturbances to basal ganglia function, indicating the vulnerability of this brain region. The diagnosis is rarely indicated by the simple phenotypic appearance of chorea, and can be challenging, with many patients remaining undiagnosed. Clues to diagnosis may be found in the patient’s family or medical history, on neurologic examination, or upon laboratory testing and neuroimaging. Increasingly, advances in genetic medicine are identifying new disorders and expanding the phenotype of recognized conditions. Although most therapies at present are supportive, correct diagnosis is essential for appropriate genetic counseling, and ultimately, for future molecular therapies.
Curr Neurol Neurosci Rep (2011) 11:385–395 DOI 10.1007/s11910-011-0202-2 Published online: 5 April 2011
