Incorporation of Biomarker Assessment in Novel Clinical Trial Designs: Personalizing Brain Tumor Treatments
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Evanthia Galanis &Wenting Wu & Jann Sarkaria & Susan M. Chang & Howard Colman & Daniel Sargent & David A. Reardon
- چاپ و سال / کشور: 2010
Description
Advances in molecular genetics have aided the identification of potential biomarkers with significant clinical promise in neurooncology. These advances and the evolution of targeted therapeutics necessitate the development and incorporation of innovative clinical trial designs that can effectively validate and assess the clinical utility of biomarkers. In this article, we review the use and potential of several such designs in neurooncology trials in order to support the development of personalized treatment approaches for brain tumor patients
Curr Oncol Rep (2011) 13:42–49 DOI 10.1007/s11912-010-0144- Published online: 3 December 2010
