Hematopoietic Cell Regulation of Osteoblast Proliferation and Differentiation
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Monique Bethel & Edward F. Srour & Melissa A. Kacena6
- چاپ و سال / کشور: 2011
Description
The last several decades have revealed numerous interactions between cells of the hematopoietic lineage and osteoblasts (OBs) of the mesenchymal lineage. For example, OBs are important players in the hematopoietic stem cell (HSC) niche and OBs are known to impact osteoclast (OC) development. Thus, although much is known regarding the impact OBs have on hematopoietic cells, less is known about the impact of hematopoietic cells on OBs. Here we will review this reciprocal relationship: the effects of hematopoietic cells on OBs. Specifically, we will examine the impact of hematopoietic cells such as HSCs, lymphocytes, and megakaryocytes, as well as the hematopoietic cell–derived OCs on OB proliferation, differentiation, and function.
Curr Osteoporos Rep (2011) 9:96–102 DOI 10.1007/s11914-011-0048-1 Published online: 1 March 2011
