Genome-Wide Association Studies of Alcohol Dependence and Substance Use Disorders
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Jens Treutlein & Marcella Rietschel
- چاپ و سال / کشور: 2011
Description
Genome-wide association studies (GWAS) currently represent the most systematic approach to genetic research into complex disorders. They can detect associations of common variants in genomic regions in the absence of an a priori assumption. Most of the GWAS of addiction performed to date have focused on alcohol dependence or smoking behavior. Four GWAS of alcohol dependence have been published thus far, and only two single nucleotide polymorphisms have received modest support of replication in a subsequent study. Many more GWAS have been conducted for smoking behavior. One large, single GWAS and metaanalyses of the phenotype “smoking quantity” have generated convincing evidence for the contribution of variants in genes for cholinergic nicotinic receptor subunits. This article focuses on GWAS of alcohol addiction and provides an overview of GWAS of other substance abuse disorders.
Curr Psychiatry Rep (2011) 13:147–155 DOI 10.1007/s11920-011-0176-4 Published online: 21 January 2011
