Clinical Assessment and Management of Cytopenias in Lupus Patients
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Alana B. Levine & Doruk Erkan
- چاپ و سال / کشور: 2011
Description
Anemia, leukopenia, and/or thrombocytopenia can occur as a result of non-immune- and immunemediated mechanisms in patients with systemic lupus erythematosus. Although the differential diagnosis of these cytopenias is broad and warrants a thorough evaluation, lupus disease activity and medications are common etiologic factors. Corticosteroids are the mainstay of initial treatment for immune-mediated hemolytic anemia and severe thrombocytopenia; immunosuppressive agents such as mycophenolate mofetil or azathioprine are often added for their steroid-sparing effects. Rituximab and intravenous immunoglobulin can be considered for refractory cytopenias based on a large body of anecdotal evidence and case series. Newer biologic agents such as belimumab or epratuzumab have yet to be studied specifically in systemic lupus erythematosus–mediated hematologic disorders
Curr Rheumatol Rep (2011) 13:291–299 DOI 10.1007/s11926-011-0179-5 Published online: 19 April 2011
