Pathogenesis of Dermatomyositis: Role of Cytokines and Interferon
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Lily Kao & Lorinda Chung & David F. Fiorentino
- چاپ و سال / کشور: 2011
Description
Dermatomyositis is a systemic autoimmune disease that primarily affects skeletal muscle, skin, and the lungs. Dermatomyositis is characterized by autoantibodies, tissue inflammation, parenchymal cell damage and death, and vasculopathy. This review focuses on recent advances regarding the role of cytokines and interferon in the pathogenesis of the disease. Evidence for the role of a particular cytokine is based on data showing dysregulated levels in tissue and/or blood; correlation with histopathologic or clinical markers of disease activity; and, rarely, clinical efficacy of targeted cytokine inhibitors. Many of the recent advances pertain to elucidation of the role of interferons in both muscle and skin disease in dermatomyositis. Although a great deal of progress has been made regarding the role of interferon in the disease, many critical questions remain unanswered.
Curr Rheumatol Rep (2011) 13:225–232 DOI 10.1007/s11926-011-0166-x Published online: 12 February 2011
