Androgen Suppression Strategies for Prostate Cancer: Is There an Ideal Approach?
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Mohamed Ismail & Matthew Ferroni & Leonard G. Gomella
- چاپ و سال / کشور: 2011
Description
Androgen suppression therapy (AST) was first described in 1941 as a treatment of prostate cancer (PCa) and remains the mainstay of therapy in patients with hormone-naïve metastatic disease. It also is used in locally advanced or recurrent disease and in combination with radiation therapy in patients with higher-risk features. Several approaches to AST have been developed as a result of increased understanding of the pathways controlling testosterone production. Increased recognition of the side effects has resulted in strategies to minimize complications associated with AST. Attempts to reduce AST adverse effects include intermittent hormonal therapy and methods to reduce amount of intracellular androgens without reducing the circulating testosterone levels.
Curr Urol Rep (2011) 12:188–196 DOI 10.1007/s11934-011-0178-0 Published online: 8 March 2011
