Impact of Genetics on the Diagnosis and Treatment of Renal Cancer
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Eric A. Singer & Gennady Bratslavsky & Lindsay Middelton & Ramaprasad Srinivasan & W. Marston Linehan
- چاپ و سال / کشور: 2010
Description
Kidney cancer is a heterogeneous disease comprised of a number of histologic subtypes, each associated with unique genetic mutations, clinical features, and sensitivity to treatment. By examining families affected with the hereditary kidney cancer syndromes von Hippel- Lindau, hereditary papillary renal cell carcinoma, hereditary leiomyomatosis and renal cell carcinoma, and Birt-Hogg- Dubé, researchers have been able to identify the genes responsible for these syndromes. This work has revealed that kidney cancer is fundamentally a metabolic disorder, and as such, novel targeted therapies specific to their molecular biology have been developed and employed in both the hereditary and sporadic forms of renal cell carcinoma.
Curr Urol Rep (2011) 12:47–55 DOI 10.1007/s11934-010-0156-y Published online: 3 December 2010
