Update on Prostate Brachytherapy: Long-term Outcomes and Treatment-related Morbidity
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Johnny Kao & Jamie A. Cesaretti & Nelson N. Stone & Richard G. Stock
- چاپ و سال / کشور: 2011
Description
Current research in prostate brachytherapy focuses on five key concepts covered in this review. Transrectal ultrasound-guided prostate brachytherapy assisted by intraoperative treatment planning is the most advanced form of image-guided radiation delivery. Prostate brachytherapy alone for low-risk prostate cancer achieves lower prostate-specific antigen (PSA) nadirs than intensitymodulated radiotherapy (IMRT) or protons while maintaining durable biochemical control in about 90% of patients without late failures seen in surgically treated patients. As an organ-conserving treatment option, seed implant results in a lower rate of erectile dysfunction and urinary incontinence than surgery that has been validated in several recent prospective studies. Combined IMRT and seed implant has emerged as a rational and highly effective approach to radiation-dose escalation for intermediate- and high-risk prostate cancer. Preliminary results suggest that seed implantation may play a role in improving outcomes for historically poor-prognosis locally advanced and recurrent prostate cancers
Curr Urol Rep (2011) 12:237–242 DOI 10.1007/s11934-011-0183-3 Published online: 12 March 2011
