Pioglitazone: A Promising Therapeutic Tool in Sodium Taurocholate-Induced Severe Acute Pancreatitis
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Ping Xu Kai Xu Jing Wang Jin-Ping Jiang Ling-Quan Chen
- چاپ و سال / کشور: 2010
Description
Background Studies suggest that peroxisome proliferator- activated receptor c(PPARc) ligands may represent a therapeutic option in acute pancreatitis, yet most of them have been prophylactic administrated. Aims To evaluate the therapeutic effect of pioglitazone in rats with severe acute pancreatitis induced by sodium taurocholate. Methods Severe acute pancreatitis (SAP) was induced in male Sprague–Dawley rats by the retrograde injection of 5% sodium taurocholate into the pancreatic duct. After SAP was induced, pioglitazone was injected intraperitoneally and its role on the severity of inflammatory response and pancreatic injury was investigated. Amylase activity, inflammatory cytokines production, pathological changes of pancreas, PPARc mRNA expression, and the survival rate were examined. Results Treatment with pioglitazone decreased the level of amylase activity, proinflammatory factors IL-6 and TNF-a, ameliorated pancreatic histological score, and upregulated the expression of PPARc mRNA. The survival rate in the early stage of severe acute pancreatitis was also improved. Conclusions Pioglitazone can be used as a therapeutic drug and relieve the damages caused by SAP, which suggests PPARc ligand-pioglitazone offers a potent approach for the treatment of severe acute pancreatitis.
Dig Dis Sci (2011) 56:1082–1089 DOI 10.1007/s10620-010-1393-0 Received: 9 April 2010 / Accepted: 11 August 2010 / Published online: 8 September 2010
