Expression and Prognostic Significance of CD151, c-Met, and Integrin alpha3/alpha6 in Pancreatic Ductal Adenocarcinoma
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Guang-Hui Zhu Chen Huang Zheng-Jun Qiu Jun Liu Zhi-Hua Zhang Ning Zhao Zheng-Zhong Feng Xiu-Hong Lv
- چاپ و سال / کشور: 2010
Description
Background CD151, c-Met, and integrin alpha3/alpha6 are all involved in the hepatocyte growth factor (HGF)/ c-Met signal pathway, which plays an important role in the malignant progression of tumors. Aims The purpose of this study was to explore the expression and prognostic significance of these proteins in pancreatic ductal adenocarcinoma (PDAC). Methods We used immunohistochemical methods to investigate the expression patterns of CD151, c-Met, and integrin alpha3/alpha6proteins in 71 patients with PDAC and in ten samples of normal pancreatic tissue. We also assessed correlations between these proteins and clinicopathological parameters and survival of PDAC patients using various statistical methods. Results CD151, c-Met, and integrin alpha3/alpha6 were all overexpressed in PDAC. CD151 and c-Met overexpressions were significantly associated with TNM stage (p = 0.001 and p = 0.038, respectively) and lymph node invasion (p = 0.000, p = 0.012, respectively). A significant positive linear correlation was found between CD151 and c-Met (r = 0.583; p = 0.000), integrin alpha3 (r = 0.457; p = 0.000), and integrin alpha6 (r = 0.671; p = 0.000). Overexpression of CD151, c-Met, integrin alpha3, or integrin alpha6 was related to poor survival of PDAC patients (p = 0.000, p = 0.000, p = 0.005, and p = 0.003, respectively), and CD151 and c-Met were independent factors in prognosis of PDAC. Conclusions CD151, c-Met, and integrin alpha3/alpha6 were all overexpressed in PDAC. CD151 and c-Met might be new molecular markers to predict the prognosis of PDAC patients.
Dig Dis Sci (2011) 56:1090–1098 DOI 10.1007/s10620-010-1416-x Received: 16 June 2010 / Accepted: 26 August 2010 / Published online: 7 October 2010
