Polymorphisms in Interleukin-1B (IL-1B) and Interleukin 1 Receptor Antagonist (IL-1RN) Genes Associate with Gastric Cancer Risk in the Chinese Population
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Bang-Shun He Yu-Qin Pan Yong-Fei Xu Chan Zhu Li-Li Qu Shu-Kui Wang
- چاپ و سال / کشور: 2011
Description
Background Gastric cancer is one of the most common malignancies afflicting the Chinese population. Polymorphisms in interleukin-1B (IL-1B) and interleukin-1 receptor antagonist (IL-1RN) genes have been associated with increased gastric cancer risk. Aims A case–control study enrolled 392 gastric cancer patients and 508 healthy were carried out to investigate the association between polymorphisms in IL-1B and IL-1RN and gastric cancer risk. Methods Polymerase chain reaction (PCR)-restriction fragment length polymorphism was used for detection of two potentially functional polymorphisms (IL-1B-31 and IL-1B-511) in the IL-1B gene promoter and PCR was used for detection of the variable tandem repeat in the second intron of IL-1RN. Results The data showed that the IL-1B-31CC genotype increased gastric cancer risk to an adjusted odd of 2.27 (95% CI, 1.49–3.46), IL-1B-31CT to 1.48 (95% CI, 1.01–2.16) and IL-1B-31CT/CC to 1.68 (95% CI, 1.17–2.40), while IL-1B- 51TT genotype associated with increased gastric cancer risk to an adjusted odd of 2.53 (95% CI, 1.67–3.84), IL-1B- 511TC to 1.45 (95% CI, 1.02–2.06), and IL-1B-511TC TT/ TC to 1.72 (95% CI, 1.23, 2.39). Furthermore, IL-1RN heterogeneity genotype (IL-1RN2L) was associated with gastric cancer risk to an adjusted odd of 1.70 (95% CI, 1.05–2.74) compared to the wild-type homozygote (IL-1RNLL). In addition, H. pylori infection enhanced gastric cancer risk through these SNPs. Conclusions The data from the current study demonstrated that the genotype CC or CT of IL-1B-31, TT or CT of IL-1B-511, and 2L of IL-1RN increased risk of gastric cancer in this Chinese population and the risk was further enhanced by H. pylori.
Dig Dis Sci (2011) 56:2017–2023 DOI 10.1007/s10620-010-1557-y Received: 4 September 2010 / Accepted: 31 December 2010 / Published online: 18 January 2011
