Relationships Among the Lactulose Breath Test, Intestinal Gas Volume, and Gastrointestinal Symptoms in Patients with Irritable Bowel Syndrome
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Young Hoon Youn Jung Soo Park Jae Hoon Jahng Hyun Chul Lim Jie-Hyun Kim Mark Pimentel Hyojin Park Sang In Lee
- چاپ و سال / کشور: 2011
Description
Background and Aims Irritable bowel syndrome (IBS) patients frequently complain of gas-related symptoms, and the lactulose breath test (LBT) is a test that assesses the amount of fermented gas generated by bacteria in the bowel. We aimed to assess the relationship among intestinal gas volume, LBT result, and gastrointestinal symptom score in healthy control and functional bowel disorder (FBD) subjects. Method In 84 IBS subjects, 24 FBD subjects other than IBS, and 25 healthy controls, a symptom questionnaire that enquired about seven main symptoms, plain abdominal radiography and a LBT were checked on the same day. The intestinal gas volume was calculated as the gas volume score (GVS) with a digitalized image of plain supine abdominal radiographs. Results The GVS was greater in the LBT (?) group compared to the LBT (-) group (P = 0.02). The GVS was greater in the FBD and IBS groups than in the control group (P\0.01). The GVS showed low but positive correlations with the severity and frequency of bloating, flatulence, abdominal pain, constipation, and tenesmus (P\0.05). The severity of flatulence (P = 0.02) and the frequency of bloating (P = 0.02) in the LBT (?) group were significantly higher than those in the LBT (-) group. Conclusions Subjects with positive LBT had more gasrelated symptoms and greater gas volume scores. Gasrelated symptoms, positive LBT and increased GVS were significantly associated to each other. These findings can broaden the understanding of the pathophysiologic mechanisms of gas-related symptoms in IBS
Dig Dis Sci (2011) 56:2059–2066 DOI 10.1007/s10620-011-1569-2 Received: 27 August 2010 / Accepted: 6 January 2011 / Published online: 15 January 2011
