Absence of Mucosal Inflammation in Uncomplicated Diverticular Disease
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Luca Elli Leda Roncoroni Maria Teresa Bardella Claudia Terrani Antonella Bonura Michele Ciulla Stefano Marconi Luca Piodi
- چاپ و سال / کشور: 2011
Description
Background Uncomplicated diverticular disease is a common condition in patients older than 50 years. Symptoms are aspecific and overlapping with those of irritable bowel syndrome. Nowadays, patients are often treated with antinflammatory drugs (5-aminosalicilic acid). Aim Our purpose was to evaluate the presence of inflammation in the colonic mucosa of patients with symptomatic uncomplicated diverticular disease compared with subjects without diverticula. Methods Endoscopic biopsies of colon from 10 patients with symptomatic uncomplicated diverticular disease and 10 from subjects without diverticula (controls) were taken. Specimens were homogenised and IL2, IL4, IL5, IL8, IL10, IL12p70, IL13, IFN gamma, TNF alfa (searchlight multiplex technique), TGF beta, transglutaminase type 2 and caspase 9 were measured. Histochemistry for transglutaminase type 2 and TUNEL were performed on the histological sections, in addition to morphologic evaluation, as markers of tissue remodelling and apoptosis. For statistical analysis Student’s t test and Spearman correlation test were used. Results No histological differences were detected between the patients with an uncomplicated diverticular disease and controls. Mean values of mucosal cytokines and of the other tested parameters did not show statistically significant differences between patients with uncomplicated diverticular disease and controls. Conclusions Even if based on a small number of patients, the study demonstrates the absence of inflammation in the mucosa of subjects affected by uncomplicated diverticular disease.
Dig Dis Sci (2011) 56:2098–2103 DOI 10.1007/s10620-010-1547-0 Received: 9 November 2010 / Accepted: 18 December 2010 / Published online: 8 January 2011
