The Level of HBV DNA at Month 12 Is an Important Predictor of Virological Breakthrough During Adefovir Monotherapy in Chronic Hepatitis B Patients with Lamivudine Resistance
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Moon-Chan Kim Seok Won Jung Jung Woo Shin Neung Hwa Park
- چاپ و سال / کشور: 2011
Description
Background and Aims The aim of this study was to determine the optimal time and HBV DNA levels during the treatment period for prediction of virological breakthrough (VBT) 3 years after adefovir monotherapy in chronic hepatitis B (CHB) patients with lamivudine resistance. Methods We consecutively analyzed HBV DNA levels within 12 months in 210 lamivudine-resistant CHB patients treated with adefovir monotherapy for more than 36 months. Results VBT, genotypic adefovir mutations, and virologic responses were observed in 52 (24.8%), 37 (17.6%), and 117 (55.7%) cases within 3 years of treatment, respectively. Using receiver-operating characteristic curve analysis, HBV DNA levels at month 12 had a greater power (AUROC, 0.839; 95% CI, 0.759–0.919; p\0.001) to predict VBT after 3 years of treatment. The best cut-off value of HBV DNA levels at month 12 for predicting VBT at 3 years of treatment was 200 IU/ml with a sensitivity and negative predictive value of 88.5 and 94.3%, respectively. Using this time and cut-off value, VBT had developed in six (5.7%) of the patients with HBV DNA levels \200 IU/ml (n = 105) and 46 (43.8%) of the patients with HBV DNA levels C200 IU/ml (n = 105) at month 12 (p\0.001). Moreover, virological response or HBeAg seroconversion remained higher at 82.9 and 81.2%, respectively. Conclusions In patients who were switched to adefovir monotherapy as rescue therapy for lamivudine resistance before the introduction of current therapeutic guidelines, measurements of HBV DNA levels at month 12 should be performed to predict VBT. Early termination of adefovir monotherapy should be considered for patients who still have HBV DNA C200 IU/ml (3 log10 copies/ml) at 12 months of treatment.
Dig Dis Sci (2011) 56:1215–1221 DOI 10.1007/s10620-010-1537-2 Received: 10 October 2010 / Accepted: 17 December 2010 / Published online: 8 January 2011
