Liver Transplantation for Alcohol-Related Cirrhosis: A Single Centre Long-Term Clinical and Histological Follow-Up
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : M. Schmeding C. Heidenhain R. Neuhaus P. Neuhaus U. P. Neumann
- چاپ و سال / کشور: 2010
Description
Background Alcohol-induced liver cirrhosis is one of the leading indications for liver transplantation today. Due to the general organ shortage and continuous deaths on the waiting list there has been some debate on the issue of indication and ethical problems. It was the aim of this study to critically analyse the outcome of patients with alcoholic cirrhosis transplanted at our centre with special emphasis on alcoholrecurrence frequency and long-term histological follow-up. Methods Three hundred five patients who received LT for alcoholic cirrhosis at our institution were followed over a period of 3–10 years after transplantation. Biopsies were taken 1, 3, 5, and 10 years after LT. Specimens were analysed and staged concerning inflammation, rejection, fatty involution, and fibrosis/cirrhosis. Clinical characteristics as well as serological parameters, immunosuppressive protocols, rejection episodes, and patient and graft survival were recorded. Results Recurrence of alcohol abuse occurred in 27% of all patients analysed. Regardless of alcohol consumption, 5-year graft and patient survival were excellent; after 10 years abstinent patients showed significantly better survival (82% vs. 68%; P = 0.017). Histological changes were slightly more pronounced among recurrent drinkers, no significant difference regarding inflammation or fibrosis was detected. Conclusion Patients undergoing LT for alcohol-induced cirrhosis show excellent long-term survival rates with stable graft function. Alcohol recurrence impairs long-term prognosis; however, compared to other patient sub-populations (HCC, HCV) results are clearly above average.
Dig Dis Sci (2011) 56:236–243 DOI 10.1007/s10620-010-1281-7 Received: 25 February 2010 / Accepted: 4 May 2010 / Published online: 25 May 2010
